Next generation neural mass models: bridging the scales from micro to macroscopic dynamics
|Founding Body:||Human Brain project, co-funded by
European Union Horizon 2020
|Total grant:||€ 96k|
|Principal Investigator:||Simona Olmi|
|Other participants:||Viktor Jirsa (University of Aix-Marseille)|
The project aims to be a clever blend between classic unifying multi-scale frameworks and pyramid-style approaches thanks to the following strengths:
In this framework will be developed a next generation neural mass model encompassing short-term plasticity (STP), which has not yet been implemented in TVB. The resulting plasticity models can then be integrated into single neuron or population models and will serve as a starting point for including more realistic and biologically relevant aspects (e.g. pulsatile interactions or transmission delays). In particular the work plan includes the following steps: a) validation and extension of the next generation neural mass model developed in  to take into account finite-size fluctuations of the microscopic synaptic variables , synaptic delays , electrical coupling via gap junctions  and chemical synapses ; b) parameter optimization; c) application to Showcase 1 (WP1) in SGA3 to reproduce both resting states and task-related states; d) application to Showcase 2 (WP1) in SGA3 to construct personalized brain models of epileptic patients.
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