NAR: Energetic funnel facilitates facilitated diffusion
Massimo Cencini has published Energetic funnel facilitates facilitated diffusion in Nucleic Acid Research.
Gene transcription is regulated by proteins – Transcription Factors (TFs) – that by binding to short target sequences are able to promote or impede the binding of RNA-Polymerase (RNAP) and, consequently, activate or repress tran-
scription. Fast and accurate control of gene expression is crucial for many biological functions, and relies on the ability of TFs to rapidly find their transcription factor binding site (TFBS) among a multitude of competing DNA sequences,
and to establish with it a stable complex.… Read the rest